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The human body has natural defenses against DMT - they are called MonoAmine Oxidase. Their role is to destroy the DMT as soon as it gets inside the body, whether it it released by the pineal gland or whether it it taken from the outside.

When you ingest DMT, it takes a long time for it to get to the brain, because it has to go through the digestive system. During that time, normally, The MAO destroy all the DMT, and none of it makes it to the brain. When you smoke DMT, it is a much faster route to the brain so the MAO don't have time to destroy it all - but they do after some time. That is why the DMT experience is so short-lived.

The role of the MAOI (MonoAmine Oxidase Inhibitor) is to keep the MAO from destroying the DMT. It makes it possible to ingest the DMT and have it come to the brain intact.

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Q: Why do you need an MAOI with oral DMT?
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