Pharmacokinetic/Pharmacodynamic
Pharmaceutical phase, Pharmacokinetic phase and Pharmacodynamic phase
Pharmacokinetic information about a drug allows the determination of an optimal dosage regimen and form of administration that will produce a specified drug concentration in the body
Pharmacokinetic studies are performed to understand how a drug is absorbed, distributed, metabolized, and excreted in the body. This information is critical in determining the appropriate dose, dosing frequency, and potential interactions with other medications. Pharmacokinetic studies also help in evaluating the safety and efficacy of a drug in different populations.
Any medicine or drug that can interfere in absorption, distribution, metabolism and excretion of drugs and alter their original effect is call pharmacokinetic interactions.
The SAR (Structure-Activity Relationship) of cholinergic drugs involves a quaternary ammonium group for interaction with the receptor, an acetyl group for substrate recognition, and an appropriate spacer between these groups for optimal receptor binding. Modifications to these structural features can affect the drug's potency, selectivity, and pharmacokinetic properties.
Peter I. D. Lee has written: 'Pharmacokinetic analysis' -- subject- s -: Pharmacokinetics
The absorption, distribution, metabolism and excretion of drugs are the primary four parameters of pharmacokinetics.
Digoxin is a drug used to treat heart rhythm problems. It can also treat heart failure and angiotensin converting enzymes.
Interaction force is the force acting between two objects as a result of their interaction, such as gravitational, electromagnetic, or nuclear forces. Interaction distance is the distance between the centers of mass of the interacting objects at which the interaction force becomes significant enough to influence their behavior.
Drug and drug receptor interactions can be measured. Complex pharmacodynamic equations combine with measurable pharmacokinetic values to determine the overall effect of a drug
Pharmacokinetic phase: involves the absorption, distribution, metabolism, and elimination of the drug in the body. Pharmacodynamic phase: refers to the drug's interaction with its target receptors and the subsequent biochemical and physiological effects. Phase of termination: marks the decline of drug effects as the body clears the drug through metabolism and excretion.