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Benadryl is safe to use in dogs up to 1 mg per pound (so a 25 mg tablet is safe for a dog that weighs up to 25 pounds). But if the label has the words "Sinus" or "Headache" on it, it could also contain a decongestant or acetaminophen, both of which can be toxic to dogs.
Just leave her, or maybe observe depend on how much he takes because Benadryl-D is not a dangerous drug knorr a poison.
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