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The combination of amantadine and central nervous system stimulants (e.g., amphetamines or decongestants) may cause increased central nervous stimulation or increase the likelihood of seizures.

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Q: What drug interactions does amantadine have?
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What is the difference between Amantadine and Amantadine hydrochloride?

Actually they are the same substance. A chloride ion is introduced to amantadine to become amantadine hydrochloride. This will be helpful to increase the solubility of amantadine. Most drugs are absorbed faster by the body if they are salts, especially hydrochloride salts and sulfate salts