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What are the bioisosteres of the Me group?

Anonymous

∙ 7y ago

Updated: 11/14/2022

They include the F, Cl, NH2, and OH group.

Wiki User

∙ 7y ago

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Related Questions

What is a bioisosterism?

Bioisosterism is a process in drug design where one functional group or atom is substituted with another to maintain the desired pharmacological properties of a drug. The goal is to improve drug potency, selectivity, or pharmacokinetic properties while minimizing unwanted side effects. Bioisosteres are structurally similar but not identical compounds that can mimic the original pharmacophore.

Are pyrimidine and triazine rings bioisosteres?

Yes, pyrimidine and triazine rings are considered bioisosteres because they have similar geometries and sizes, allowing them to interact with biological targets in a comparable manner. They can be used interchangeably in drug design to modulate properties such as solubility, bioavailability, and potency.

Why are bioisosteres used in drug design?

Bioisosteres are molecules with a similar shape that have a similar biological effect. Their functional groups can be systematically replaced to investigate which structures have the desired properties such as high selectivity, less adverse effects, more metabolic stability, and less toxicity. The usage of bioisoteres can lead to a more simplified route to produce new drugs.

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If at a competition group "a" defeats group "b", and group "b" defeats group "c" then group "a" will have to defeat group "C"

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