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What is a bioisosterism?
Bioisosterism is a process in drug design where one functional group or atom is substituted with another to maintain the desired pharmacological properties of a drug. The goal is to improve drug potency, selectivity, or pharmacokinetic properties while minimizing unwanted side effects. Bioisosteres are structurally similar but not identical compounds that can mimic the original pharmacophore.
Are pyrimidine and triazine rings bioisosteres?
Yes, pyrimidine and triazine rings are considered bioisosteres because they have similar geometries and sizes, allowing them to interact with biological targets in a comparable manner. They can be used interchangeably in drug design to modulate properties such as solubility, bioavailability, and potency.
Why are bioisosteres used in drug design?
Bioisosteres are molecules with a similar shape that have a similar biological effect. Their functional groups can be systematically replaced to investigate which structures have the desired properties such as high selectivity, less adverse effects, more metabolic stability, and less toxicity. The usage of bioisoteres can lead to a more simplified route to produce new drugs.
Which group is the group of death?
Which group is the group of death of soccer
What dose array mean?
a group a group a group a group and a big fat group and last but not least a groupA Group
What are the 8 major groups of the m240b?
Barrel group Bolt group Operating rod group Shoulder group Buttstock group Bipod group Feed tray group Receiver group
What is -OH group?
The -OH group is called the hydroxyl group
Examples for transitive property of equality?
If at a competition group "a" defeats group "b", and group "b" defeats group "c" then group "a" will have to defeat group "C"
What is the group of carbon sodium neon and chlorine?
Carbon: group 14Sodium: group 1Neon: group 18Chlorine: group 17
What are all the blood groups?
Group A, Group B, Group AB, Group O
A -CH3 group is a group?
A -CH3 group is a methyl group. It consists of a carbon atom bonded to three hydrogen atoms, making it a simple alkyl group.
What are carboxylic group?
-COOH group is the carboxilic group.
