What are the central nervous system and respiratory depression risks from mixing paroxetine and hydrocodone?
We can find nothing in the literature to indicate a problem with
paroxetine (Paxil) and hydrocodone. You should know, however, that
hydrocodone exaggerates the symptoms of depression. Since
paroxetine is often prescribed for depression and similar
disorders, it would be a good idea to talk this over with your
physician and/or pharmacist.