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YOU cannot use tramadol in combination with methadone. It is an opiate antagonist which if you are taking methadone can send you into instant severe withdrawl. I do not have the answer for methadone and fentanyl combination but do not use the tramadol methadone combination. If you do or have you are in for a very very scary experience. There are many pain meds you cannot mix with methadone. Take it from a life long methadone patient who has experienced what it is like to mix an opiate antagonist with methadone........Do not try it............................
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