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I weaned myself off of Wellbutrin (was taking 300 mg XL daily) by taking my usual dose for a week, then taking my usual dose every other day for a week and then stopping altogether. I expected to have flu-like symptoms so I planned a couple days off work during the third week, my first week of not taking any. I was a little tired but nothing too bad. I just planned a couple of rest days. Another experience: I was on Wellbutrin for six months. I started on 150 XL / day then reduced to 100 / day and finally for one week to 75. My doctor told me I could stop immediately. I did try to stop the 150XL on my own and ten days later I was manic (but I also was trying to stop Klonopin at the same time). My guess is the manic feeling was more related to the cessation of Klonopin without a long term taper (especially after being on it for over two years).

Most articles on here, and on Medline seem to indicate that there is not a discontinuation syndrome like the other SSRIs. They do reference flu like symptoms but not a return to depression and anxiety. I am off Wellbutrin because the medication, even in low doses, really made me anxious, jittery and I dropped 25 pounds (which is fine).

I'm still on Trazadone for sleep until further notice.

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Q: How do you wean yourself off of Wellbutrin?
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