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You can take plain Mucinex with plain acetaminophen. There are no adverse interactions between the two. This is under the assumption you have no health conditions that restrict you from taking either of these meds by themselves, and you are taking no other meds that would interact with either.

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12y ago
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10y ago

Musinex is a brand name for guaifenesin. It is a drug in itself.

Guaifenesin can be taken by itself or with acetaminophen (Brand name Tylenol). Basic Musinex does not contain Tylenol, but some cold remedies contain both guaifenesin and acetaminophen. You have to read the Active Ingredients list on the package to know whether what you are taking contains both.

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Q: Does mucinex contain Tylenol
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