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It seems that almost any medication CAN affect coumadin levels in SOME people. Percocet (oxycodone/acetaminophen) will not typically affect Coumadin but in higher doses the acetaminophen (Tylenol) component of Percocet may increase INR levels slightly. You should get your INR checked if you take a lot of Percocets or if your dose is increased or decreased significantly.

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Q: Can you take percacets while on coumadin?
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