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Yes, there is an interaction between those 2 drugs. You should never stop prednisone without speaking with your doctor, this drug has to be stopped over many days. Cocaine is a powerful stimulant that may lead to cardiac problems. These problems might be exacerbated by prednisone use (depending on the dose..) Prednisone is also a stimulant working on adrenals (epinephrine, norepinephrin). You should avoid those 2 drugs together.

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Q: Can you take cocaine and Prednisone together?
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