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Technically yes, but it is not recommended. The two drugs basically do the same thing, and, as opposed to mixing say naproxen, Acetaminophen, and ibuprofen, there would be no benefit - just more drowsiness and dry-mouth.

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โˆ™ 12y ago
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โˆ™ 10y ago

I wouldn't take Benadryl and Sudafed (Pseudoephedrine) together if you're looking for something non-drowsy. Instead, go to the store and buy Claritin-D or Zyrtec-D. They both have psuedoephedrine in it, which acts as a decongestant. If you already have the Sudafed, then you can just buy the generic version of Claritin or Zyrtec. Wal-Mart offers it on their $4 generic list sold over the counter. Loratadine (Claritin) or Cetirizine (Zyrtec).

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โˆ™ 14y ago

Depending on the dosing.

I assuming that you are using these drugs recreationally, which is not safe on its own.

If you are allergic, or ever had a bad trip on either of the drugs, dont do it.

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โˆ™ 15y ago

Yes you can take them both. I take 10mg Zyrtec in the Morning and one benadryl in the evening when my Allergies are bad.

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Q: Can you mix Benadryl and dextromethorphan?
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