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I don't know exactly what you mean by "major" weight gain, but, I've been on coumadin for about 8 years now, and within the first 6 months of taking it I gained about 10 lbs. without changing my diet or exercise routine. I've tried to lose it, but it won't go away. I told my doc. this and he said that according to the 'experts' out there, coumadin doesn't cause weight gain. But, he also said that it was the only thing that could've caused it in me based on everything I've told him. He assured me it was most likely water weight instead of fat. Hope this helps!
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