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Antibiotics usually do not make you depressed. If you are sick enough to need an antibiotic, however, you can certainly feel tired, sluggish, and "blue!" If you have never suffered from these feelings before, I would be more likely to blame your infection rather than the antibiotic. Your body is using up all its energy to fight off the infection, so you don't have anything left over to make you feel alert and peppy.

Typical side effects from any antibiotic, including cephalexin, are more usually the GI effects such as nausea or vomiting, diarrhea, and upset stomach.

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Q: Can cephalexin make you depressed
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