"Acetylcholinesterase" production results in the production of a glucosteroid inhibitor.
Neostigmine is a reversible acetylcholinesterase inhibitor, meaning it blocks the activity of acetylcholinesterase enzyme and prevents the breakdown of acetylcholine at the neuromuscular junction. This leads to an increase in acetylcholine levels, enhancing muscle contractions and improving neuromuscular transmission.
Acetylcholinesterase inhibitors, of course! These include ambinonium (Mytelase), physostigmine, neostigmine (Prostigmin, Vagostigmin), galantamine (Razadyne, Reminyl, Nivalin), pyridostigmine, Tacrin (Cognex), donepezil (Aricept), edrophonium (Tensilon, Enlon, Reversol) and rivastigmine (Exelon), and others.
Physostigmine is an inhibitor of acetylcholinesterase which breaks down acetylcholine in the synaptic cleft of the neuromuscular junction. It is used in the treatment of Alzheimer's and memory loss.
Donepezil is an example of an acetylcholinesterase inhibitor commonly used in the treatment of Alzheimer's disease. It works by increasing the levels of acetylcholine in the brain, thereby improving cognitive function and memory.
The mechanism of acetylcholinesterase (AChE) inhibitor side effects such as weakness is due to excessive accumulation of acetylcholine at cholinergic synapses. This leads to overstimulation of muscarinic and nicotinic receptors, causing symptoms like muscle weakness. The excess acetylcholine can also affect neuromuscular junction function, contributing to weakness.
Acetylcholinesterase is pronounced uh-SEET-uhl-KOH-lin-ES-ter-ays.
neostigmine
Acetylcholine is degraded by acetylcholinesterase
ACHe
Nerve agents are compounds that have the capacity to inactivate the enzyme acetylcholinesterase (AChE)
Acetylcholinesterase is dangerous to humans as it attacks nerves and causes a loss of use in the affected area. Poisons and venoms contain these properties.