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First...Benadryl for toddlers is regarded as a bad thing unless your doctor has stated it's safe.
I have a 22 month old daughter who is 35 inches tall...and 33 lbs (she's very tall for her age).
During her last major cold, her pedi told us she could take the normal Tylenol dose depending on whether it was infant or childrens suspension and 3/4 tsp of Benadryl.
If she's not taking the Tylenol, a 1tsp dose of Benadryl was allowed, but the combo of full doses of both caused her to be so drowsy she couldn't function.
I'm not a doctor, so please don't take my advice as solid or golden, but I know under medical supervision they will sometimes allow for the combo.
I just gave my 20 month old both. Then I thought about it and now I'm freaking out thinking I may have made a wrong call. She had a sinus infection and is fussy from pain. I hope to see your answers
As drugs, Benadryl and Prednisone shouldn't interact dangerously. But- they may have interactions with food or drink, so the best thing to do when taking multiple medications, especially for a two year old, is to consult their pediatrician or a pharmacist.
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