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Few studies have demonstrated the secretion of FGF 19 from the GB. Classically FGF 19is secreted on distal ileum, playing a key role in postprandial negative feedback loops in the enterohepatic circuit, down regulating bile acids (BA) synthesis and providing relaxation of the gallbladder (GB). Moreover Estrogen Receptor and Progesterone Receptors are expressed in GB mucosa establishing it as an endocrine organ.

Dr Soumen Das

Breast & Endocrine Surgeon

Kolkata,India

drsoumen_das@Yahoo.co.in

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Q: Why is the gallbladder a major organ of the endocrine system?
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