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Erythropoietin (EPO) is secreted in response to chronic hypoxia, and EPO stimulates the production of RBCs. Therefore a secondary polycythaemia is seen in COPD and other chronic hypoxia states eg congestive heart failure, ventricular septal defects, sleep apnoea and pulmonary hypertension.

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βˆ™ 12y ago
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βˆ™ 14y ago

When there is inadequate ability of the lungs to absorb oxygen (due to pulmonary conditions such as emphysema/COPD), the body compensates by producing more red blood cells (with which to carry oxygen). Polycythemia means "high red blood cell count".

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Q: Why erythrocytosis occur with COPD?
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Is erythrocytosis associated with anemia?

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Why would a COPD patient have a higher percentage of red blood cells than a healthy person without COPD?

A COPD patient may have a higher percentage of red blood cells due to chronic low oxygen levels (hypoxemia) in the blood. The body compensates by producing more red blood cells to improve oxygen transport. This is known as secondary erythrocytosis or secondary polycythemia.


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