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if we consider the formation of RBCs Erythropoietin, produced by the kidneys, signals RBC formation in the red bone marrow is required.
but if we consider the activation of rbc so haemoglobin is essential, in which haemoglobin consiats of single molecule so we can also say for the activation of rbc that:-
IRON------>HAEMOGLOBIN------>RBC
and RBC are produced as
BY KIDNEY------->ERTHROPROTEIN------>RBC
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