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Caffeine, by a wide margin. Caffeine is the most commonly used psychoactive drug in the world. Approximately 80% of the world's population consumes it on a daily basis.

There is, however, considerable discussion about whether or not caffeine is in fact addictive. Those who hold that it is point to the undeniable withdrawal symptoms that make it difficult to stop using coffee and other caffeine-containing substances.

The cons say that there is no proven harm to caffeine consumption, and that this lack of harm and lack of interference with user's lives put it out of the addiction category.

There is ongoing research. The Diagnostic and Statistical Manual IV lists caffeine addiction as a "proposed diagnosis," and encourages more research.

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Q: What is more common caffeine or nicotine?
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