Myoclonic epilepsy with ragged-red fibers, also known as MERRF is a mitochondrial disorder (therefore, it is maternally inherited) which affects many parts of the body but in particular, muscle and the nervous system.
MERRF is usually characterized by muscle twitches (hence, myoclonus), muscle weakness and generally patients experience progressive stiffness or spasticity.
from what we know about the mitochondria why do you think the muscles and the nervous system are the predominant tissue affect in the disease known as myoclonic epilepsy with reagged red fibers (MERFF)
The Red Skelton Show - 1951 Beneath His Ragged Shirt Lies Ragged Underwear 18-20 was released on: USA: 11 February 1969
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Basically the time under stress brings in red muscle or the slow twitch fibers into action. If the movement is controlled and the set goes longer the red fibers are used.. If the movement is explosive and heavy then the white fibers are used. For example squatting for 15 rep range incorporates red fibers of the thighs very well
Slow-twitch fibers are also called red oxidative fibers. These fibers are more efficient at using oxygen to generate energy and are suited for activities requiring endurance and sustained low-intensity effort.
Slow oxidative fibers are typically red in color due to their high myoglobin content, which gives them their oxidative capacity for sustained contractions over long periods of time.
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The diagnosis of MELAS is usually suspected on clinical grounds. However, confirmation of the diagnosis usually requires a muscle or brain biopsy. The muscle biopsy shows characteristic ragged red fibers; Brain biopsy shows stroke-like changes. And look for serum creatinine kinase and lactic acid in blood and CSF
The strength of joints limits the size of red muscle fibers.
Presence of myoglobin
Humans have both in their bodies.
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