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Breathing and Lung Mechanics

Ventilation is the exchange of air between the external environment and the alveoli. Air moves by bulk flow from an area of high pressure to low pressure. All pressures in the respiratory system are relative to atmospheric pressure (760mmHg at sea level). Air will move in or out of the lungs depending on the pressure in the alveoli. The body changes the pressure in the alveoli by changing the volume of the lungs. As volume increases pressure decreases and as volume decreases pressure increases. There are two phases of ventilation; inspiration and expiration. During each phase the body changes the lung dimensions to produce a flow of air either in or out of the lungs.

The body is able to change the dimensions of the lungs because of the relationship of the lungs to the thoracic wall. Each lung is completely enclosed in a sac called the pleural sac. 2 structures contribute to the formation of this sac. The parietal pleura is attached to the thoracic wall where as the visceral pleura is attached to the lung itself. In-between these two membranes is a thin layer of intrapleural fluid. The intrapleural fluid completely surrounds the lungs and lubricates the two surfaces so that they can slide across each other. Changing the pressure of this fluid also allows the lungs and the thoracic wall to move together during normal breathing. Much the way two glass slides with water in-between them are difficult to pull apart, such is the relationship of the lungs to the thoracic wall.

The rhythm of ventilation is also controlled by the "Respiratory Center" which is located largely in the medulla oblongata of the brain stem. This is part of the autonomic system and as such is not controlled voluntarily (one can increase or decrease breathing rate voluntarily, but that involves a different part of the brain). While resting, the respiratory center sends out action potentials that travel along the phrenic nerves into the diaphragm and the external intercostal muscles of the rib cage, causing inhalation. Relaxed exhalation occurs between impulses when the muscles relax. Normal adults have a breathing rate of 12-20 respirations per minute.

The Pathway of Air

When one breathes air in at sea level, the inhalation is composed of different gases. These gases and their quantities are Oxygen which makes up 21%, Nitrogen which is 78%, Carbon Dioxide with 0.04% and others with significantly smaller portions. In the process of breathing, air enters into the nasal cavity through the nostrils and is filtered by coarse hairs (vibrissae) and mucous that are found there. The vibrissae filter macroparticles, which are particles of large size. Dust, pollen, smoke, and fine particles are trapped in the mucous that lines the nasal cavities (hollow spaces within the bones of the skull that warm, moisten, and filter the air). There are three bony projections inside the nasal cavity. The superior, middle, and inferior nasal conchae. Air passes between these chonchae via the nasal meatuses.

Air then travels past the nasopharynx, oropharynx, and laryngopharynx, which are the three portions that make up the pharynx. The pharynx is a funnel-shaped tube that connects our nasal and oral cavities to the larynx. The tonsils which are part of the lymphatic system, form a ring at the connection of the oral cavity and the pharynx. Here, they protect against foreign invasion of antigens. Therefore the respiratory tract aids the immune system through this protection. Then the air travels through the larynx. The larynx closes at the epiglottis to prevent the passage of food or drink as a protection to our trachea and lungs. The larynx is also our voicebox; it contains vocal cords, in which it produces sound. Sound is produced from the vibration of the vocal cords when air passes through them.

The trachea, which is also known as our windpipe, has ciliated cells and mucous secreting cells lining it, and is held open by C-shaped cartilage rings. One of its functions is similar to the larynx and nasal cavity, by way of protection from dust and other particles. The dust will adhere to the sticky mucous and the cilia helps propel it back up the trachea, to where it is either swallowed or coughed up. The mucociliary escalator extends from the top of the trachea all the way down to the bronchioles, which we will discuss later. Through the trachea, the air is now able to pass into the bronchi

[edit] Inspiration

Inspiration is initiated by contraction of the diaphragm and in some cases the intercostals muscles when they receive nervous impulses. During normal quiet breathing, the phrenic nerves stimulate the diaphragm to contract and move downward into the abdomen. This downward movement of the diaphragm enlarges the thorax. When necessary, the intercostal muscles also increase the thorax by contacting and drawing the ribs upward and outward.

The active increase of the thorax changes the stability set up in a resting lung. As the thoracic wall moves away from lung which increases the space between the thoracic wall and lung and decreases the pressure in the intrapleural cavity. This decrease in pressure causes the pressure in the alveoli to become greater than the elastic recoil that is inherent in lung tissue. Thus, when contraction of the diaphragm and the intercostal muscles actively increase the size of the thorax, the lungs are passively forced to expand. This expansion increases the size of the alveoli which decreases pressure in the alveoli. Pressure within the alveoli is now lower than atmospheric pressure which allows air to move into the lungs through the structures discussed above.

[edit] Expiration

During quiet breathing, expiration is normally a passive process and does not require muscles to work. When the lungs are stretched and expanded, stretchy receptors within the alveoli send inhibitory nerve impulses to the medulla oblongata, causing it to stop sending signals to the rib cage and diaphragm to relax and rise. This elastic recoil causes the lungs and chest cavity to shrink and increase the air pressure within the lungs. This increased positive air pressure pushes the air out of the lungs. Expiration happens as the diaphragm relaxes. Although the respiratory system is primarily under involuntary control, and regulated by the medulla oblongata, we have some voluntary control over it also. This is due to the higher brain function of the cerebral cortex.

When under physical or emotional stress, more frequent and deep breathing is needed, and both inspiration and expiration will work as active processes. Additional muscles in the rib cage forcefully contract and push more air out of the lungs. (This cannot occur during rest.) In addition to deeper breathing, when coughing or sneezing we exhale forcibly. Our abdominal muscles will contract suddenly (when there is an urge to cough or sneeze), raising the abdominal pressure. The rapid increase in pressure pushes the relaxed diaphragm up against the pleural cavity. This causes air to be forced out of the lungs.

Another function of the respiratory system is to sing and to speak. Our exert of conscious control over our breathing is what allows us to speak and sing.

Basically:

If the atmospheric pressure is greater then the pressure in the lungs, the air will be expelled out of the lungs very quickly.

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12y ago
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10y ago

On inhalation, the pressure within the lungs is less than the atmospheric pressure due to contraction of the diaphragm and the intercostal muscles and expansion in the chest cavity. This increase in the negative pressure, caused by the difference in pressure, generates airflow.

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12y ago

Under ordinary conditions, the air that is in the lung is exhaled.

If you hold your breath while ascending on Scuba, the pressure differential can cause the rupture of the lung and a condition called pneumothorax.

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14y ago

Exhalation

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Q: What happens when pressure in the chest cavity becomes greater than atmospherics pressure?
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