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HBsAg non-reactive does NOT mean immune to hepatitis B. To understand this we have to discuss what exactly HBsAg is.

The hepatitis B virus has several components. It is an encapsulated virus, meaning that its central DNA core is protected by an outer shell. This shell is sometimes called the "surface". On this surface are some antigens, which are simply proteins that induce an immune response in the body. We abbreviate these antigens as HBsAg, which is shorthand for "hepatitis B surface antigen". If a blood test reveals that there are no detectable hepatitis B surface antigens, this simply means that the individual has no evidence of being currently infected with hepatitis B. Otherwise, there would be some hepatitis B surface antigens (with hepatitis B DNA inside them) floating around in the bloodstream.

To determine if a person is immune to hepatitis B, we must draw a different test. This test checks for the presence of antibodies to the hepatitis B surface antigens. Sometimes this is abbreviated as HBAb, or as Hepatitis B IgG. If the patient has antibodies to Hepatitis B surface antigens, and has no detectable HBsAg in their bloodstream, then it is likely that they are immune. But be careful! Simply having Hepatitis B surface antibodies does not indicate immunity! It may mean that the person is actually infected with Hep B. This is why both tests are necessary to document immunity.

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βˆ™ 15y ago
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βˆ™ 12y ago

A non-reactive result indicates lack of specific immune response to Hepatitis

B surface antigen or vaccine. Such individuals are presumed to be non-immune

and therefore susceptible to Hepatitis B infection.

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βˆ™ 15y ago

Does a non reactive result on an Hep Bs Ag test means that the vaccination was successfull or not?

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βˆ™ 17y ago

non reactive hep c does that mean i have been cured within 8 combination therapys

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βˆ™ 10y ago

A non-reactive Hepatitis B titer means a negative test. If the titer was reactive, at the very least, you would know you were directly exposed to Hepatitis B.

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βˆ™ 12y ago

its mean you don't have hepatitis C

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Q: What does a non reactive hep b surface antibody mean?
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