The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
Sex-linked genes
the X chromosome
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
The X chromosome. That's why it's more common in males; females have 2 X chromosomes, but males only have 1. So if a woman has the hemophilia mutation on one of her chromosomes, she probably won't be affected by it.
A carrier for hemophilia is a female who carries the genetic mutation for hemophilia on one of her X chromosomes, but does not exhibit symptoms of the condition herself. Carriers can pass on the gene mutation to their children, resulting in hemophilia in male offspring. Testing can confirm carrier status.
hemophilia
when does the duplication of chromosomes occur?
The gene for hemophilia A is found on the X chromosome (it is a sex-linked recessive disorder). Women have two X chromosomes and men have one X chromosome. A woman with hemophilia (very rare) would have the mutated gene on both of her X chromosomes. This means that all of their children, both male and female would have hemophilia.
Since Hemophilia A is an "X Chromosome" disease and women have two "X" Chromosomes, women with only one "X" Chromosome with the disorder would be carriers of the disease but not affected by it. Women with both "X" Chromosomes with the disorder would be very rare.
If a woman has hemophilia, it means she inherited one affected X chromosome from each of her parents. This suggests that her father is likely a carrier of the hemophilia gene on his X chromosome, and her mother is either a carrier of the gene on one of her X chromosomes or has hemophilia herself.
Men Have XY chromosomes. women have XX chromosomes. To get Hemophilia, all of your X chromosomes have to be affected. as you can see, it is much easier for a man to get it than a woman.