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What are the pharmacological advantages of telmisartan over valsartan?
Wiki User
∙ 13y ago
telmisartan lowered both systolic and
diastolic BP to a greater extent than did valsartan
Wiki User
∙ 13y ago
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What is increased dosing required over time to produce the same pharmacological effect?
pseudotolerance
What is the difference between olmesartan and telmisartan?
Telmisartan has proven mortality benefits in patients at high risk of cardiovascular events, regardless of blood pressure drops (see ONTARGET trial)Telmisartan and olmesartan are indicated for use in patients with hypertension, and telmisartan has an additional indication for the prevention of cardiovascular morbidity and mortality in patients over 55 years with- coronary artery disease- peripheral artery disease- previous stroke- previous TIA- high risk diabetes with evidence of end-organ damage, such as renal (see approved TGA indications)Olmesartan does not have any additional indications.Telmisartan has sustained blood pressure lowering effects, which last for up to 48 hours (see Product Information)Telmisartan has a longer half-life than olmesartan (see Product Information)Telmisartan has the lowest renal clearance, olmesartan is contraindicated in patients with severe renal impairment (see Product Information)ROADMAP Study with olmesartan raised concerns of increased myocardial infarcts, theorised to be due to the quick onset of action (see ROADMAP trial)
How are NSAIDs and acetaminophen obtained?
NSAIDs and acetaminophen are available as over-the-counter and prescription medications, and are frequently the initial pharmacological treatment for pain.
How has the medical field responded to long-term pain?
Therefore, pharmacological and other therapies have developed over time to address these aspects of disease and injury.
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