Alzheimer's disease.
The progressive death of nerve cells in the brain is associated with the formation of clumps (amyloid plaques) and tangles of protein (neurofibrillary tangles) in the brain.
Brain lesions associated with Alzheimer's disease are called amyloid plaques and neurofibrillary tangles. These are abnormal protein deposits that interfere with normal brain function and are characteristic features of the disease.
Another hallmark of Alzheimer’s disease is the presence of neurofibrillary tangles inside neurons. These involve a protein called tau, which functions like railroad ties to bind microtubule “tracks” together. In the brains of AD victims, tau abandons its microtubule-stabilizing role and grabs onto other tau molecules, forming spaghetti-like neurofibrillary tangles, which kill the neurons by disrupting their transport mechanisms. As the brain cells die, the brain shrinks. Loss of neurons in the basal forebrain is associated with a shortage of the neurotransmitter acetylcholine, and drugs that inhibit breakdown of acetylcholine slightly enhance cognitive function in AD patients.
Straighten it...you cant make a quilt if your yarn is in tangles
The duration of Tango Tangles is 720.0 seconds.
Tango Tangles was created on 1914-03-09.
Alzheimer's disease is a common neurological disorder that causes forgetfulness and memory loss. It is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain, leading to cognitive decline over time.
Both are associated with defects in the neurons. Alzheimers with amyloid plaques and neurofibrillary tangles and Lewys with nerve cells in the substantia nigra containing abnormal structures. Both have very simlar effects on the brain: *memory, *language skills, *perception, *cognitive skills including reasoning and judgment are significantly impaired.
The cast of Tangles - 2011 includes: Sara Pascale as Jesse
The gold standard for diagnosis of Alzheimer disease is through autopsy examination by an experienced pathologist. Detection of amyloid plaques in the brain by histopathology is the most conclusive diagnostic tool.
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