How is cystic fibrosis caused?

Answer 1

1. Cystic fibrosis is caused by recessive inheritance as is sickle cell disease, Tay Sachs, Phenylketonuria, Thalassemia, and Galactosemia.

(i got that ot of the book)

Cystic Fibrosis is caused by a genetic mutation.

Answer 2

It is caused by either both parents being CF carriers or one parent having CF and the other being a carrier and then the children getting it genetically. However the parents do not have to have CF to be a carrier as it is a recessive trait (if they have one CF gene and one non-CF gene, they will not have CF but there is a chance their children may if the other parent is also a CF carrier). Cystic fibrosis is a genetic disease. That means people inherit it from their parents through genes (or DNA), which also determine a lot of other characteristics including height, hair color and eye color. Genes, found in the nucleus of all the body's cells, control cell function by serving as the blueprint for the production of proteins. The defective gene that is responsible for causing cystic fibrosis is on chromosome 7. To have cystic fibrosis, a person must inherit two copies of the defective CF gene—one copy from each parent. If both parents are carriers of the CF gene (i.e., they each have one copy of the defective gene), their child will have a 25% chance of inheriting both defective copies and having cystic fibrosis, a 50% chance of inheriting one defective copy and being a carrier, and a 25% chance of not having CF or carrying the gene. Approximately 30,000 people in the United States have cystic fibrosis. An additional ten million more—or about one in every 31 Americans—are carriers of the defective CF gene, but do not have the disease. The disease is most common in Caucasians, but it can affect all races. The severity of cystic fibrosis symptoms is different from person to person. The most common symptoms are: Very salty-tasting skin

Persistent coughing, at times with phlegmFrequent lung infections, like pneumonia or bronchitisWheezing or shortness of breathPoor growth/weight gain in spite of a good appetiteFrequent greasy, bulky stools or difficulty in bowel movementsSmall, fleshy growths in the nose called nasal polypsSometimes people are told that they have Asthma or chronic bronchitis when they really have cystic fibrosis. New research shows that the severity of CF symptoms is partly based on the types of CF gene mutations (defects). Scientists have found more than 1,500 different mutations of the CF gene.

Answer 3

Cystic Fibrosis is a genetic disorder which is passed on to a child when both parents have the CF gene. There is a 1 in 4 chance of the child developing CF if both parents have the gene.

Hope this helps!

Answer 4

cystic fibrosis is basically where salts and mucus in the lungs are too thick. This paralyses the cillia that waft mucus up to be coughed up and swallowed. As a result too much mucus stays in the lungs meaning that bacteria thrive. In these conditions the bacteria can mutate into more serious forms of infections for example pnemonia. People with a certain type of cf (there is 4 strains,I think) have pancreas problems where certain enzymes aren't produced enough. usually it's lipoprotiens that digest fat. For this people have to take creon, these are capsules that contain enzymes and must be taken whenever fat is consumed. Someone with this problem would have to eat around twice the amount to sustain a normal weight. Also because they tend to eat fatty foods there is an increased risk of Diabetes. People with cf are often on heavy medication and this can eventually begin to affect their liver. Hope that helps.

Answer 5

CF is caused by a mutation in the gene cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation, ΔF508, is a deletion (Δ) of three nucleotides that results in a loss of the amino acid phenylalanine (F) at the 508th (508) position on the protein. This mutation accounts for two-thirds of CF cases worldwide and 90 percent of cases in the United States; however, there are over 1,400 other mutations that can produce CF. Although most people without CF have two working copies (alleles) of the CFTR gene, only one is needed to prevent cystic fibrosis. CF develops when neither allele can produce a functional CFTR protein. Thus, CF is considered an autosomal recessive disease.

The CFTR gene is found at the q31.2 locus of chromosome 7, is 230,000 base pairs long, and creates a protein that is 1,480 amino acids long. Structurally, CFTR is a type of gene known as an ABC gene. The product of this gene (the CFTR) is a chloride ion channel important in creating sweat, digestive juices and mucus. This protein possesses two ATP-hydrolyzing domains which allows the protein to use energy in the form of ATP. It also contains two domains comprising 6 alpha helices apiece, which allow the protein to cross the cell membrane. A regulatory binding site on the protein allows activation by phosphorylation, mainly by cAMP-dependent protein kinase. The carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZ domain interaction.

Answer 6

Cystic fibrosis is an autosomal recessive disease. Both parents must carry a mutation in order to have a 1:4 (25%) chance of having a child with CF.

Answer 7

It causes a rash, which is followed by untrimmed toe nails. Then, you will tend to feel off balance. Finally, Cystic fibrosis will turn you into a Zombie!!

Answer 8

Cystic Fibrosis is a genetic disease, so it is caused by two parents being carriers and passing the gene to their child.