Cholinergic drugs are used for urinary retention, myasthenia gravis, glaucoma. Cholinergic drugs act like the neurotransmitter ACh (acetylcholine). Anti Cholinergic (also called Cholinergic blocking) drugs block the action of the ACh. Anti Cholinergic drugs are used foe pylorospasm & peptic ulcers, bladder overactivity, parkinson's disease
Cholinergic drugs produce the same effects as acetylcholine. Acetylcholine is the most common neurohormone of the parasympathetic nervous system, the part of the peripheral nervous system responsible for the every day work of the body.
Direct acting cholinergic drugs directly bind to and activate cholinergic receptors, while indirect acting cholinergic drugs increase cholinergic activity by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. Direct acting drugs include bethanechol and pilocarpine, while indirect acting drugs include donepezil and physostigmine.
Pharmacology is the study of drugs and their actions on the body. "Cholinergic" and "anticholinergic" are terms that refer to drugs that play a huge role in the part of the nervous system that regulates the "rest and digest" functions of the body. This part of the nervous system is the parasympathetic nervous system and the major transmitter that it uses is called acetylcholine, from whence the term "cholinergic" derives. A drug that binds and activates the acetylcholine receptor is called cholinergic, whereas a drug that blocks this receptor or blocks its downstream actions is called anticholinergic. A major nerve of the parasympathetic nervous system is the vagus nerve, the tenth cranial nerve (CN X). For this reason, cholinergic and anticholinergic drugs are commonly called vagomimetic (mimics the vagus nerve) and vagolytic (blocks vagus nerve activity), respectively. Cholinergic and anticholinergic pharmacology involves the drugs that work on the parasympathetic nervous system. These drugs are numerous and can treat a variety of diseases, from glaucoma to Alzheimer disease.
Dilation of the pupils (Mydriasis)
Cholinergic drugs should be avoided when the patient has any sort of obstruction in the urinary or digestive tracts, such a a tumor, or severe inflammation which is causing blockage.
Cholinergic drugs are used for a variety of purposes, including the treatment of myasthenia gravis and during anesthesia.
Anticholinergic drugs are substances used to help reduce and block the effects of acetylcholine. They are mainly used for the treatment of stomach cramps, motion sickness and ulcers. Some anticholinergic drugs include: Ipatropium Bromide Oxitropium Bromide Tiotropium Glycopyrrolate
anticholinergic
Cholinergic drugs
cholinergic drugs are to produce the same effects as stimulation of the parasympathetic nervous system. These effects include slowing of the heartbeat, increases in normal secretions including the digestive acids of the stomach, saliva and tears.
Indirect cholinergic drugs work by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down acetylcholine in the body. By inhibiting this enzyme, indirect cholinergic drugs increase the levels of acetylcholine available in the nervous system, leading to prolonged cholinergic effects. This can be useful in conditions such as myasthenia gravis or Alzheimer's disease.