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The hypothalamic-pituitary-gonadal axis (also HPG axis) is referring to the effects of the hypothalamus, pituitary gland, and gonads as if these individual endocrine glands were a single entity as a whole. Because these glands often behave in cooperation, physiologists and endocrinologists find it convenient and descriptive to speak of them as a single system.

The hypothalamic-pituitary-gonadal axis is a critical part in the development and regulation of a number of the body's systems, such as the reproductive, and immune systems. Fluctuations in the hormones cause changes in the hormones produced by each gland and have various widespread and local effects on the body. This axis controls development, reproduction, and aging in animals. The hypothalamus produces gonadotropin-releasing hormone (GnRH). The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.

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Q: Gonadotropin inhibitors and hypothalamic pituitarial gonadal axis?
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Which of the choices below is not a part of the hypothalamic-pituitary-gonadal axis?

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What ias the difference between gonadal hormone and gonadotropin?

Gonadal hormones are those hormones that are actually released from the gonads (ex. estrogen, testosterone). Gonadotropins are hormones that CAUSE the release of gonadal hormones, gonadotropins are released from the anterior pituitary gland(tropin means "releasing" so gonadotropin is a gonad hormone releasing hormone) an example of this would be FSH-- follicle stimulating hormone.


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The most important determinant of the onset of puberty is the activation of the hypothalamic-pituitary-gonadal (HPG) axis. This hormonal axis becomes active due to changes in the levels of hormones such as GnRH, LH, and FSH, which in turn trigger the physical changes associated with puberty. Genes, nutrition, and environmental factors can also influence the timing of puberty onset.


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