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IL-6 is relevant to many disease processes such as Diabetes, atherosclerosis, systemic lupus erythematosus, prostate cancer, and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases. The first such is tocilizumab which has been approved for rheumatoid Arthritis. Another, ALD518, is in clinical trials.

Tocilizumab (INN, or atlizumab, developed by Hoffmann-La Roche and Chugai under the trade names Actemra and RoActemra) is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R) used as an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis. Interleukin 6 is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

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Q: Expression of interlukin-6 in rheumatoid arthritis?
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