0
Add your answer:
Earn +20 pts
Is an autoimmune disorder that is characterized by a red scaly rash on the face and upper trunk?
Systemic lupus erythematosuslupus erythematosus
Autoimmune condition marked by a wolf-like facial rash and joint pain?
systemic lupus erythematosus or SLE
Which disorder is associated with a butterfly rash on the nose and cheek?
The disorder associated with a butterfly rash on the nose and cheeks is systemic lupus erythematosus (SLE). This autoimmune disease can cause inflammation in various parts of the body, including the skin. The butterfly rash is a common symptom seen in individuals with SLE.
What causes the butterfly rash in systemic lupus erythematosus?
The characteristic butterfly-rashes of SLE is caused by deposits of circulating immune complexes on the skin. This symptom usually appear on sun-exposed skin.
Systemic lupus erythematosus sounds quite nasty but what is it?
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remission. Lupus can occur at any age, and is most common in women, particularly of non-European descent. Lupus is treatable symptomatically, mainly with corticosteroids and immunosuppressants, though there is currently no cure.== == The word itself is also Latin for Wolf
What does Canis lupis familiaris mean?
Canis Lupus is the Latin name for the Grey Wolf. The disease of lupus (aka, SLE or Systemic Lupus Erythematosus) was given its name by a 19th century French doctor who thought that the butterfly-shaped facial rash (which is often an indicator for lupus) looked like the bite of a wolf. ("lupus" is Latin for wolf and "erythematosus" is Latin for red).
Is Lupus curable?
Discoid Rash As people age, they become more prone to certain diseases and illnesses. Many people experience lupus, a type of immune system disease that, depending on its severity, can adversely affect a person's life. Because of the number of people who are being diagnosed with lupus, the disease has become a very well discussed topic. Most reports focus on the type of lupus that is most severe, systemic lupus erythematosus, but they don't focus on the other types, such as discoid lupus a.k.a. discoid rash. What is Discoid Rash? Since there are a lot of different types of lupus out there, discoid lupus hasn't always been properly described. But with all of the research, it is now easy to say exactly what discoid lupus is. Discoid rash, a common part of discoid lupus, is a rash which is found on the face. It is typically a scarring rash, so someone who has discoid lupus will have a permanent scar on their face. What Does the Discoid Rash Look Like? Discoid rash is characterized by a red, butterfly like shape on the face. That explains why so many lupus groups use the butterfly as their logo-a discoid rash is literally a red butterfly rash. It doesn't always look this way, though, and some may have a more mild, different shaped pink colored rash on the face. How dark the rash is depends on how much UV exposure the person has had through their life. What Does the Discoid Rash Mean? The discoid rash means that the person who has it has an active form of lupus. When discoid lupus goes into remission, the rash will disappear. Any scars it made will remain, though. What are the Symptoms of Discoid Lupus? Discoid lupus sufferers may have several symptoms, or they may have very few, depending on the stage of the disease. You may have some or all of the following symptoms if you have discoid lupus: A rash on your face, which is either pink in color or red. It may be shaped like a butterfly. Scars on the scalp, caused by the rash. Scars on the face are also common. Severe hair loss. Scalp itchiness and peeling. A rash on some other part of your body. The discoid rash can occur anywhere on the body, so don't be surprised if it's on your neckline or legs or someplace else. Blister-like lesions around the tips of the fingers. What Causes Discoid Lupus? Doctors haven't pinpointed any one particular cause, but they believe that exposure to UV rays and skin Allergies may play a roll in discoid lupus. What Treatments? Discoid lupus isn't typically curable, but it is treatable enough so that it won't significantly hurt a person's quality of life. Treatment ranges from steroids to antimalarial drugs. Some who have had a lot of facial damage may undergo plastic surgery to remedy it, while others may need to do little more than to use makeup to cover any scars they do not want showing. Discoid lupus is not a life-threatening disease, so even if you have it, you should still be very healthy. 1. First of all I got to say that the disease is known as Discoid Lupus Erythematosus or Cutaneous Lupus Erythematosus, Discoid rash is only the first sign of Discoid Lupus. 2. Second the butterfly rash is a sign for Systemic Lupus no for Discoid or Cutaneous Lupus. 3. The ages for the appearance of Discoid or Cuatneous Lupus is between 20 to 40 years of age, and the prevalence is 4 to 1 in favor of female than males. 4. It is known that an untreated lesion could leave a scar that is permanent, but it is in any place of the body. 5. The name of Discoid Lupus come from its shape that is like a coin in its onset. 6. It is also known that people with this disease has a photosensitive reaction which exacerbate the condition. 7. It is also known by research that plastic surgery only cover a short frame of time the lesion because when the disease is active would begins the disfigurement again, so it is not a solution, 8. When a person has this disease it can overlap and the most part of the time it do it, other symptoms/diseases like depression, anxiety, social withdrawal, it change your lifestyle for ever. 9. This lesion caused sores and permanent disfigurement there is when became the onset of problems (like I said before) from diseases like depression, anxiety, social withdrawal, isolation, sadness, etc. Discoid Lupus is called the most benign part of the lupus spectro, who ever called it like this doesn't know of what they are talking about. Only a person who have it for years, and have to deal with it day to day knows what is this all about. I have Discoid Lupus Erythematosus for 29 years now, and it was not as easy as anyone could think. I always ask to myself why some lupus association has fewer information about this topic, why they do researches about the systemic part and the cutaneous part still be in ignored.
Can you pass the lupus rash to someone else?
Lupus is a serious autoimmune disease, but it is not contagious. You cannot *pass on* the lupus rash to someone else.
Does Seal still have discoid lupus?
According to the Lupus Foundation of America, IL Chapter's Website-www.lupusil.org: "Cutaneous lupus erythematosus is limited to your skin. Although cutaneous lupus can cause many types of rashes and lesions (sores), the most common kind is raised, scaly and red, but not itchy; it is called a discoid rash because the areas of rash are shaped like disks, or circles." That would be why Seal has the raised marks on his face. You can find many other answers to your questions about Lupus on this website.
Is Discoid Lupus curable?
Discoid Rash As people age, they become more prone to certain diseases and illnesses. Many people experience lupus, a type of immune system disease that, depending on its severity, can adversely affect a person's life. Because of the number of people who are being diagnosed with lupus, the disease has become a very well discussed topic. Most reports focus on the type of lupus that is most severe, systemic lupus erythematosus, but they don't focus on the other types, such as discoid lupus a.k.a. discoid rash. What is Discoid Rash? Since there are a lot of different types of lupus out there, discoid lupus hasn't always been properly described. But with all of the research, it is now easy to say exactly what discoid lupus is. Discoid rash, a common part of discoid lupus, is a rash which is found on the face. It is typically a scarring rash, so someone who has discoid lupus will have a permanent scar on their face. What Does the Discoid Rash Look Like? Discoid rash is characterized by a red, butterfly like shape on the face. That explains why so many lupus groups use the butterfly as their logo-a discoid rash is literally a red butterfly rash. It doesn't always look this way, though, and some may have a more mild, different shaped pink colored rash on the face. How dark the rash is depends on how much UV exposure the person has had through their life. What Does the Discoid Rash Mean? The discoid rash means that the person who has it has an active form of lupus. When discoid lupus goes into remission, the rash will disappear. Any scars it made will remain, though. What are the Symptoms of Discoid Lupus? Discoid lupus sufferers may have several symptoms, or they may have very few, depending on the stage of the disease. You may have some or all of the following symptoms if you have discoid lupus: A rash on your face, which is either pink in color or red. It may be shaped like a butterfly. Scars on the scalp, caused by the rash. Scars on the face are also common. Severe hair loss. Scalp itchiness and peeling. A rash on some other part of your body. The discoid rash can occur anywhere on the body, so don't be surprised if it's on your neckline or legs or someplace else. Blister-like lesions around the tips of the fingers. What Causes Discoid Lupus? Doctors haven't pinpointed any one particular cause, but they believe that exposure to UV rays and skin allergies may play a roll in discoid lupus. What Treatments? Discoid lupus isn't typically curable, but it is treatable enough so that it won't significantly hurt a person's quality of life. Treatment ranges from steroids to antimalarial drugs. Some who have had a lot of facial damage may undergo plastic surgery to remedy it, while others may need to do little more than to use makeup to cover any scars they do not want showing. Discoid lupus is not a life-threatening disease, so even if you have it, you should still be very healthy. 1. First of all I got to say that the disease is known as Discoid Lupus Erythematosus or Cutaneous Lupus Erythematosus, Discoid rash is only the first sign of Discoid Lupus. 2. Second the butterfly rash is a sign for Systemic Lupus no for Discoid or Cutaneous Lupus. 3. The ages for the appearance of Discoid or Cuatneous Lupus is between 20 to 40 years of age, and the prevalence is 4 to 1 in favor of female than males. 4. It is known that an untreated lesion could leave a scar that is permanent, but it is in any place of the body. 5. The name of Discoid Lupus come from its shape that is like a coin in its onset. 6. It is also known that people with this disease has a photosensitive reaction which exacerbate the condition. 7. It is also known by research that plastic surgery only cover a short frame of time the lesion because when the disease is active would begins the disfigurement again, so it is not a solution, 8. When a person has this disease it can overlap and the most part of the time it do it, other symptoms/diseases like depression, anxiety, social withdrawal, it change your lifestyle for ever. 9. This lesion caused sores and permanent disfigurement there is when became the onset of problems (like I said before) from diseases like depression, anxiety, social withdrawal, isolation, sadness, etc. Discoid Lupus is called the most benign part of the lupus spectro, who ever called it like this doesn't know of what they are talking about. Only a person who have it for years, and have to deal with it day to day knows what is this all about. I have Discoid Lupus Erythematosus for 29 years now, and it was not as easy as anyone could think. I always ask to myself why some lupus association has fewer information about this topic, why they do researches about the systemic part and the cutaneous part still be in ignored.
What is loompis disease?
I'm not familiar with "loompis disease". Are you perhaps talking about the disease called lupus? The technical name is systemic lupus erythematosis, and it is a multi-organ disease that features a characteristic skin rash and kidney condition, among other signs.
When was lupus first discovered?
This is a complicated question with a complicated answer. From www.lupus.org:The History Of Lupus ErythematosusMarc C. Hochberg, MD, MPHProfessor of Medicine, Epidemiology and Preventive MedicineUniversity of Maryland School of Medicine, Baltimore, MD.A selection from the Lupus Foundation of America Newsletter Article LibraryLFA Patient Education CommitteeApproved93-102The history of lupus erythematosus (LE) has been reviewed in both of the major textbooks on this disease [1,2] and was the subject of an article in this journal in 1983.[3] This article concentrates on developments in the present century which have logarithmically expanded our knowledge about the pathophysiology, clinical-laboratory features, and treatment of this disorder.The history of lupus can be divided into three periods: the classical period which saw the description of the cutaneous disorder, the neoclassical period which saw the description of the systemic or disseminated manifestations of lupus, and the modern period which was heralded by the discovery of the LE cell in 1948 and is characterized by the scientific advances noted above.Classical PeriodThe history of lupus during the classical period was reviewed by Smith and Cyr in 1988.[4] Of note are the derivation of the term lupus and the clinical descriptions of the cutaneous lesions of lupus vulgaris, lupus profundus, discoid lupus, and the photosensitive nature of the malar or butterfly rash. The term lupus (Latin for wolf) is attributed to the thirteenth century physician Rogerius who used it to describe erosive facial lesions that were reminiscent of a wolf's bite.[1,3] Classical descriptions of the various dermatologic features of lupus were made by:Thomas Bateman, a student of the British dermatologist Robert William, in the early nineteenth century;Cazenave, a student of the French dermatologist Laurent Biett, in the mid-nineteenth century; andMoriz Kaposi (born Moriz Kohn), student and son-in-law of the Austrian dermatologist Ferdinand von Hebra, in the late nineteenth century.The lesions now referred to as discoid lupus were described in 1833 by Cazenave under the term erythema centrifugum, while the butterfly distribution of the facial rash was noted by von Hebra in 1846. The first published illustrations of lupus erythematosus were included in von Hebra's text, Atlas of Skin Diseases, published in 1856.Neoclassical PeriodThe Neoclassical era of the history of lupus began in 1872 when Kaposi first described the systemic nature of the disorder:...experience has shown that lupus erythematosus ... may be attended by altogether more severe pathological changes.. and even dangerous constitutional symptoms may be intimately associated with the process in question, and that death may result from conditions which must be considered to arise from the local malady. [5]Kaposi proposed that there were two types of lupus erythematosus; the discoid form and a disseminated form. Furthermore, he enumerated various symptoms and signs which characterized the disseminated form including:subcutaneous nodules,arthritis with synovial hypertrophy of both small and large joints,lymphadenopathy,fever,weight loss,anemia, andcentral nervous system involvement. [5]The existence of a disseminated or systemic form of lupus was firmly established by the work of Osler in Baltimore [6] and Jadassohn in Vienna [7] in 1904. Over the next thirty years, pathologic studies documented the existence of nonbacterial verrucous endocarditis (Libman-Sacks disease) [8] and wire-loop lesions in patients with glomerulonephritis;[9] such observations at the autopsy table lead to the construct of collagen disease proposed by Kemperer and colleagues in 1941.[10] This terminology, collagen vascular disease, persists in usage now fifty years after its introduction.Modern PeriodThe sentinel event in the mid 1900s which heralded the modern era was the discovery of the LE cell by Hargraves and colleagues in 1948.[11] The investigators observed these cells in the bone marrow of patients with acute disseminated lupus erythematosus and postulated that the cell" ... is the result of ... phagocytosis of free nuclear material with a resulting round vacuole containing this partially digested and lysed nuclear material ..."This discovery ushered in the present era of the application of immunology to the study of lupus erythematosus.Two other immunologic markers were recognized in the 1950s as being associated with lupus:the biologic false-positive test for syphilis [12] and theimmunofluorescent test for antinuclear antibodies.[13]Moore, working in Baltimore, demonstrated that systemic lupus developed in 7 percent of 148 subjects with chronic false-positive tests for syphilis and that a further 30 percent had symptoms consistent with collagen disease. [12] Friou applied the technique of indirect immunofluorescence to demonstrate the presence of antinuclear antibodies in the blood of patients with systemic lupus.[13] Subsequently, the recognition of antibodies to deoxyribonucleic acid (DNA)[14] and the description of antibodies to extractable nuclear antigens (ENA) (nuclear ribonucleoprotein (nRNP), Sm, Ro, La), and anticardiolipin antibodies; these autoantibodies are useful in describing clinical subsets and understanding the etiopathogenesis of lupus.Two other major advances in the modern era have been the:development of animal models of lupus and therecognition of the role of genetic predisposition to the development of lupus.The first animal model of systemic lupus was the F1 hybrid New Zealand Black/New Zealand White mouse.[16] This murine (mouse) model has provided many insights into the immunopathogenesis of autoantibody formation, mechanisms of immunologic tolerance, the development of glomerulonephritis, the role of sex hormones in modulating the curse of disease, and evaluation of treatments including recently developed biologic agents such as anti-CD4 antibodies among others. Other animal models that have been used to study systemic lupus include the BXSB and MRL/lpr mice, and the naturally occurring syndrome of lupus in dogs.[17]The familial occurrence of systemic lupus was first noted by Leonhardt in 1954 and later studies by Arnett and Shulman at Johns Hopkins.[18] Subsequently, familial aggregation of lupus, the concordance of lupus in monozygotic twin pairs, and the association of genetic markers with lupus have been described over the past twenty years.[19] Presently, molecular biology techniques are being applied to the study of human lymphocyte antigen (HLA) Class II genes to determine specific amino acid sequences in these cell surface molecules that are involved in antigen presentation to T-helper cells in patients with lupus. These studies have already resulted in the identification of genetic-serologic subsets of systemic lupus that complement the clinico-serologic subsets noted earlier. It is hoped by investigators working in this field that these studies will lead to the identification of etiologic factors (e.g.,viral antigens/proteins) in systemic lupus.History of Therapy for LupusFinally, no discussion of the history of lupus is complete without a review of the development of therapy. Payne, in 1894, first reported the usefulness of quinine in the treatment of lupus.[20] Four years later, the use of salicylates in conjunction with quinine was also noted to be of benefit.[21] It was not until the middle of the twentieth century that the treatment of systemic lupus was revolutionized by the discovery of the efficacy of adrenocorticotrophic hormone and cortisone by Hench.[22]Presently, corticosteroids are the primary therapy for almost all patients with systemic lupus. Antimalarials are used principally for patients with skin and joint involvement on the one hand and cytotoxic/immunosuppressive drugs are used for patients with glomerulonephritis, systemic vasculitis, and other severe life-threatening manifestations on the other.[23] Currently, newer biologic agents are being investigated in treating patients with lupus.Thus, the history of lupus, although dating back at least to the Middle Ages, has experienced an explosion in this century, especially during the modern era over the past forty years. It is hoped that this growth of new knowledge will allow a better understanding of immunopathogenesis of the disease and the development of more effective treatments.ReferencesLahita RG. Introduction. In: Lahita RG, ed. Systemic Lupus Erythematosus.ew York: John Wiley and Sons. 1987; 1-3.Talbott JH. Historical background of discoid and systemic lupus erythematosus. In: Wallace DJ, Dubois EL, eds. Lupus Erythematosus. Philadelphia: Lea & Febiger. 1987; 3-11.Boltzer JW. Systemic lupus erythematosus. I. Historical aspects. MD State Med J 1983; 37:439.Smith CD, Cyr M. The history of lupus erythematosus from Hippocrates to Osler. Rheum Dis Clin North Am 1988; 14:1.Kaposi MH. Neue Beitrage zur Keantiss des lupus erythematosus. Arch Dermatol Syphilol 1872; 4:36.Osler W. On the visceral manifestations of the erythema group of skin diseases (third paper). Am J Med Sci 1904; 127:1.Jadassohn J. Lupus erythematodes. In: Mracek F, ed. Handbach der Hautkrakheiten. Wien: Alfred Holder, 1904; 298-404.Libmann E. Sacks B. A hitherto undescribed form of volvular and mural endocarditis. Arch Intern Med 1924; 33:701.Baehr G, Klemperer P, Schifrin A. A diffuse disease of the peripheral circulation usually associated with lupus erythematosus and endocarditis. Trans Assoc Am Physicians 1935; 50:139.Klemperer P. Pollack AD, Baehr G. Pathology of disseminated lupus erythematosus. Arch Path (Chicago) 19481; 32:569.Hargraves MM, Richmond H, Morton R. Presentation of two bone marrow elements: The tart cell and the LE cell. Proc Staff Meet Mayo Clin 1948; 23:25.Moore JE, Lutz WB. The natural history of systemic lupus erythematosus: An approach to its study through chronic biological false positive reactions. J Chron Dis 1955; 2:297.Friou GJ. Clinical application of lupus serum nucleoprotein reaction using fluorescent antibody technique. J Clin Invest 1957; 36:890.Deicher HR, Holman HR, Kunkel HG. The precipitin reaction between DNA and a serum factor in SLE. J Exp Med 1959; 109:97.Tan EM, Kunkel HG. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 1966; 96:404.Bielschowsky M, Helyer BJ, Howie JB. Spontaneous haemolytic anemia in mice of the NZB/BL strain. Proc Univ Otago Med School 1959; 37:9.Hahn BH. Animal models of systemic lupus erythematosus. In: Wallace DJ, Dubois EL, eds. Lupus Erythematosus. Philadelphia: Lea & Febiger. 1987; 130-57.Arnett FC, Shulman LE. Studies in familial systemic lupus erythematosus. Medicine 1976; 55:313.Hochberg MC. The application of genetic epidemiology to systemic lupus erythematosus. J Rheumatol 1987; 14:867-9.Payne JF. A post-graduate lecture on lupus erythematosus. Clin J 1894; 4:223.Radcliffe-Crocker. Discussion on lupus erythematosus. Br J Dermatol 1898; 10:375.Hench PS. The reversibility of certain rheumatic and non-rheumatic conditions by the use of cortisone or of the pituitary adrenocorticotrophic hormone. Ann Intern Med 1952; 36:1.Lockshin MD. Therapy for systemic lupus erythematosus. N Engl J Med 1991; 324:189.
