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Cold sores are caused by a virus, and polysporin is not active against viruses, so it won't work for cold sores.

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13y ago
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13y ago

Polysporin is an antibacterial agent, and cold sores are viral, so it is not effective for treating cold sores.

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13y ago

Neosporin won't heal cold sores as it is anti bacterial, not anti viral.

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Q: Does polysporin work on cold sores?
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