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Spina bifida doesn't follow a strict inheritance pattern, but hereditary factors do play some role, though it is not completely understood yet.

Mothers who have had one child with spina bifida have a 3-4% chance of their next child having spina bifida, while the general population only has a 0.1-0.2% chance. In the case a pregnant woman has a family history of spina bifida, it is recommended that they take a higher dose of folic acid than other pregnant women. Here again, folic acid plays a role in preventing neural tube defects (like spina bifida), but the mechanism is not well understood.

Also, for an unknown reason, it is more prevalent in female children than in male children.

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Q: Does Spina Bifida generate from the mother or father of the infant?
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