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Before 1980's you used to treat typhoid fever with Chloramphenicol antibiotic for 10 to 14 days. It is a 'bacteriostatic' antibiotic and there used to be many cases of chronic carrier. Few used to relapse and responded well to chloramphenicol again. Then there was emergence of chloramphenicol resistant typhoid fever. It was a serious threat to health system. Fortunately fluroqunoline group of antibacterials came to the rescue. And most cases can be managed with this antibacterial drug. This being 'bactericidal' drug you do-not have many carriers of typhoid fever. Another drug being ceftriaxone injections is also 'bactericidal' antibiotic. And you do-not have many cases of chronic carrier of typhoid fever. You treat the typhoid carriers with one of the 'bactericidal' drug. But, if you happen to find a person of typhoid fever for 40 years, please do not get surprised. As in Biology this can easily happen. ( It is interesting to read the story of 'Typhoid Merry' from USA.)
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