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Implanted polypropylene mesh (PP) in a large subset of patients causes a chronic foreign body reaction (FBR). The tissues around the implant are damaged by the oxidation process used by the body to try rid the body of the biomaterial that is not being accepted by the patients' body.
The degradation products of the oxidation are free hydroxyl radicals. The oxidation process degrades the PP and it can become brittle, shrink and have brittle edges fragment and migrate in the patient. Patients experience mesh migration, erosions, extrusions, chronic infections and many symptoms of Implant Syndrome. A simple explanation would be to compare this process as to how a splinter festers and gets moved out of the body. Chemical irritation added to mechanical irritation sets the body up for a state of constant inflammation. The immune system is constantly trying to attack the foreign body, as well as infections safely encapsulated with the mesh implant that cells trying to attack the bacteria cannot penetrate because of encapsulation or small mesh fiber size the cells cannot enter. States of chronic inflammation are associated with autoimmune disease pathogenisis, and cancer. A lack of long term studies regarding the systemic response of PP mesh degradation has left patients to research and share their health status with each other. Many report they have been diagnosed with Lupus, Rheumatoid Arthritis, and Fibromyalgia post mesh implantation. Many report developing Asthma post mesh implantation, and those with pre-existing autoimmune diseases before PP mesh implantation find their autoimmune disease symptoms exacerbated post mesh PP implantation.
Yes it can. Immune responses can be recurring infections. Formation of biofilms as the body tries to protect it self. Septecemia often follows from recurring infections of the biofilm. Degradation of the materials that enter the blood stream. Polypropylene in the brain. Yes it does cross the blood brain barrier. Arthritis, Gravis, and other immune responses have been reported.
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