Is the unemployment office open the day after Christmas?
Technically the day after Thanksgiving is not a federal holiday,
so in some situations unemployment offices may be open the day
after Thanksgiving. The bottom line is, this will vary from state
to state, as unemployment is a state administrated benefit
regulated by the states individually. I can say that in Washington
state, however, they are closed. Many other states will likely be
closed after Thanksgiving either as an added bonus for their
employees, or as a cost-cutting measure.
To get a definite answer for your particular state I would
suggest searching your state's website, but it is likely they will
be closed.