Nothing. A hypothesis is just a guess as to a possible explanation of something. If it's wrong, it's wrong. No big deal.
If you still desire to explain the thing, you should develop a new hypothesis.
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If an experiment does not confirm his hypothesis, the scientist should report this honestly. Even if the results confirmed the hypothesis, further testing should be done by him or others to gather more data.
if the hypothesis is proven to be correct or incorrect
Reject the hypothesis.
If the data from an investigation does not support the original hypothesis then either:The method of investigation may be flawed and may need to be changed and repeated.The interpretation of the data may be incorrect and should be reviewed.The hypothesis needs to be reevaluated to possibly conform to the data.
just admit you were wrong, and start over, because a hypothesis is what you think might happen