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As potassium leaves the neuron, the inside of the cell will become progressively more negative, which will attract the positive potassium ions, preventing further exodus. If this electrical force is great enough, it will actually draw potassium ions from the outside of the cell back inside.

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Q: What happens when potassium (K ) leaves the neuron?
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The chief positive intracellular ion in a resting neuron?

The chief positive intracellular ion in a resting neuron is potassium (K+). At rest, the neuron has a higher concentration of K+ inside its cell membrane compared to outside. This creates a negative membrane potential, which is crucial for maintaining the resting state of the neuron.


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Why increasing extracellular potassium ion reduces the net diffusion of potassium ion out of neuron through the potassium leak channel?

Increasing extracellular potassium ion concentration will create a smaller concentration gradient across the cell membrane, making it less favorable for potassium ions to move out of the neuron through the leak channels. The leak channels are gated by both membrane voltage and concentration gradients, so alterations in extracellular potassium levels can impact the electrochemical equilibrium that regulates potassium movement. Ultimately, this can result in a reduced net diffusion of potassium ions out of the neuron.


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