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Jack Daniel (1846-1911) was a moonshiner, founder of Jack Daniel's Distillery, and maker of the famous sour MASH Tennessee whiskey known by his name. He died from "blood poisoning", also known as septicemia, that was the result of an infection that spread to his entire body from an infected toe. Until penicillin was discovered in 1928, people often died of simple bacterial infections, that are not often fatal today thanks to penicillin and other antibiotics.

It is a myth that he died from alcohol poisoning. It is often said that his infected toe was the result of kicking his safe in anger when he forgot the combination and could not get the safe open.

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