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If you want it to taste anything like the same, no. However, if you like Guiness more than you like wine, that may not be a bad thing.

Wine is generally slightly higher in alcohol content than beers or stouts, and that could impact how much of the other marinade ingredients get dissolved and how well they penetrate, but it's not a huge difference and I wouldn't expect that big an impact from it.

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10y ago
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Q: Can you use Guinness instead of wine for a marinade?
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