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Capsaicin is a powerful skin irritant, it can also irritate the airways, and yes, over exposure can be fatal. In order to kill an average adult, he or she would need to ingest a huge amount of capsaicin, the oral lethal dose for humans is thought to be around 0.5 - 5 g/kg so it's improbable to ingest a lethal amount via chili pepper or through a topical ointment. The symptoms of capsaicin intoxication include convulsions, cyanosis (blue skin) and difficulty breathing.

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Q: Can consuming excessive amounts of capsaicin kill a human?
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