Lady Macbeth could be very persuasive. She suggests on the one hand that he would not be very manly if he did not do the murder, and on the other that they are unlikely to be suspected.
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Macbeth agrees to kill King Duncan because of his ambition for power and the manipulation by his wife, Lady Macbeth. He desires to fulfill the witches' prophecy of becoming king and is persuaded by Lady Macbeth's questioning of his masculinity. Ultimately, Macbeth's own ambition and the influence of Lady Macbeth drive him to commit regicide.