Gatsby tells Nick that Daisy accidentally hit her while they were driving his car, but he is going to take the blame. As a result, Tom fuels the fire by telling George where he can find Gatsby--the man who supposedly killed his wife--and George shoots Gatsby before taking his own life. Check out the link for more in-depth explanations.
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Myrtle is killed by Daisy Buchanan when she hits her with a car driven by Gatsby. Daisy is trying to run away from a tense confrontation and accidentally hits Myrtle. However, it is Gatsby who takes responsibility for the accident to protect Daisy.