Curley's wife and Crooks.
Maybe you should have read the book.
Chat with our AI personalities
The character who is portrayed as lonely in "Of Mice and Men" is Curley's wife. She is isolated on the ranch because the other characters, particularly the men, see her as a nuisance and a threat to their dreams and aspirations. Her loneliness stems from her lack of companionship and the feeling of being trapped in her marriage.