Nwoye's new name symbolizes not only his conversion to Christianity, but also his role as the first son of many who will eventually convert. Isaac was Abraham's first son, with Abraham being the ancestral father of a great nation of Israelites; Nwoye was Okonkwo's first son.
Further, the famous story of Abraham and Isaac called upon Abraham to sacrifice his son to god. Isaac's brush with death, was much like Nwoye being cast out of his family, and being treated as dead by his father. Nwoye is reborn as a Christian with a new name.
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