Put paper towels all over the seat first. There are products sold for this purpose, if you get some you won't have to worry next time.
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it would be impossible unless you had a toilet bigger than you!
Water and waste
No you can't
If the toilet is sitting solid on the floor, you don't need to. I would use latex instead of silicone because if you should ever have to pull the toilet, it would be much easier. One reason not to seal it down would be if the wax ring should ever fail. You could have a lot of damage to the floor before you noticed the leak.
It will more than likely plug the toilet and/or drain line and cause a flood and backup of the sewer