Use of cefixime and clavulanic acid combination?
cefixime and clavulanic acid can be used as a second line
therapy where cefixime alone is not able to show it's bacteriocidal
activity. Cefixime comes under beta lactum antibiotic category and
gets degrade inpresence of beta lactumase enzyme, bacterias have
developed resistance against cefixime by producing beta lactamase
and ESBLs. Clavulanic acid is an irreversible inhibitor of beta
lactamase enzyme and have mild antibiotic activity. when this
combination is used, clavulanic acid inhibits beta lactamase enzyme
and allow cefixime work as a bacteriocidal. the combination is very
useful against cefixime resistant becteria. more research work is
required to understand the further use of this combination and also
to find out the superiority of this combination over Amoxi+Clav
combination.