"Eso es lo que pasa", for "that's what's happening". If you mean literally "up" as in "Upstairs" or "overhead", "Eso es lo que está arriba".
You could say "Eso es lo que pasa". If you literally mean "That is the direction of up", then you could say " Eso es arriba".
if you mean to say it in a way that you are tryin to teach someone a lesson, then you say, "eso es lo que te pasa" but if you mean it in a literal sense, as in you are telling someone that is the outcome, then you can say, "eso es lo que te sale"
Que es eso means 'what is that'.
"¿Qué significa eso?" It literally means, "What does that mean?"
"Que está pasando?" ?Que pasa?
That is what I wanted.
What's up neighbor
What classes do you have after lunch?
"Que pasa muchacho" means "what's up man."
This is what I do.
¿QUÉ PASA, CHIQUITA? (CORRECT spelling) --- What's the matter, dear / baby?