Karen Little is not in the Hebrew Bible. But if you are asking how to write "Karen Little" in Hebrew, it's קרן ליטל (read from right to left). The name Keren is in Job 42:14.
Karen = קרן
Hebrew Scripture
Karen has no meaning in Hebrew, but it's very close to the Hebrew name Keren (קרן), which means "ray of light" or "horn".
Shuk (שוק)
It occurs in the Hebrew text, but it's probably a name from another language.
The Tanakh; the Tanach; the Hebrew scriptures; the Jewish Bible.
Karen Ericson's birth name is Karen Huston Heassler.
Karen Rousso's birth name is Karen Dulberg.
Karen Kwiatkowski's birth name is Karen Unger.
Karen Rosin's birth name is Karen Green.
Karen Angle's birth name is Karen Smedley.