'What is going on?' would be何ãŒèµ·ã“ã£ã¦ã‚‹ï¼Ÿ (nani ga okotteru?) in Japanese. However, this sentence is very casual. A more polite alternative would be何ãŒèµ·ã“ã£ã¦ã¾ã™ã‹ (nani ga okottemasu ka).
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It is spelled "Doushita no?" and this sentence reflects a certain personality in the way it is spoken. There are several ways to phrase the same basic vocabulary (doushita is "why") and this particular phrase can be translated to "What's the matter?"
Another way of asking what's wrong is by asking, "(Is everything/are you) okay?" which would be, "Daijoubu ka?"
You can say something to the effect of "watashi ga machigaeta," or "I made a mistake."